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Vivalytic
Vivalytic MPXV test

Rapid and Easy Detection of Monkeypox

Qualitative real-time PCR test for the detection of Monkeypox Virus and non-variola Orthopoxvirus species

MPXV

Vivalytic MPXV - a rapid and easy solution to support the global response to Monkeypox

Monkeypox is a viral zoonotic disease caused by Monkeypox Virus (MPXV) that is endemic in West and Central African countries. There have been several reported cases of travel-associated monkeypox in non-African countries in recent years (1). In May 2022, this pattern changed and a multi-country outbreak without known epidemiological links to West or Central Africa was observed with over 79.480 reported Monkeypox cases in several countries worldwide until November 2022 (2). In July 2022, the World Health Organization (WHO) declared Monkeypox an international public health emergency (3).

After eradication of smallpox, MPXV remains the most pathogenic poxvirus with two known major phylogenetic clades: Clade I (formerly Congo Basin/Central African clade and Clade II (formerly West African clade), with subclades IIa and IIb, with the latter considered as the cause of the current 2022 global outbreak (4).

Besides direct, close, and sustained contact with MPXV infected persons, sexual contact is considered an important transmission mode in the current outbreak (5).

The fully automated Vivalytic MPXV test is a qualitative real-time PCR test to be used to detect viral nucleic acids of Monkeypox Virus and non-variola Orthopox species in eNAT® transport medium.

Pathogens detectable with Vivalytic MPXV

  • Monkeypox Virus (Clade I, Clade II)
  • Non-variola Orthopoxvirus species (Cowpox Virus, Ectromelia Virus, Monkeypox Virus, Taterapox Virus, Vaccinia Virus)

Vivalytic MPXV – Fast laboratory testing for outbreak containment

  • Time to result in 45 Minutes
  • Only a few steps from sample to result
  • No further laboratory equipment needed
  • Reduced risk of infection for the user
  • Two target approach: Detection of MPXV and non-variola Orthopoxvirus species (including MPXV)

For Research Use Only.

Not intended for diagnostic use.

(1) Sah et al. Pathogens. 2022 Aug 17;11(8):924

(2) https://worldhealthorg.shinyapps.io/mpx (website WHO, status 10.11.2022)

(3) https://reliefweb.int/report/world/who-emergency-appeal-monkeypox-july-2022-june-2023 (website WHO, status 10.11.2022)

(4) Happi et al. PLoS Biol. 2022 Aug 23;20(8)

(5) Huang et al. Signal Transduct Target Ther. 2022 Nov 2;7(1):373

The advantages at a glance

Vivalytic stands for high efficiency and safety with minimum effort. The unique Vivalytic platform provides ideal assistance for everyday work in clinics, practices, and laboratories.

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Comprehensive results

The Vivalytic MPXV test utilises a two target approach to detect different orthopoxvirus species.

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High usability

The minimalistic design, easy handling and comprehensive depiction of the results ensure a high level of usability.

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Easy handling

Like all Vivalytic tests, the Vivalytic MPXV test is fully automated. This allows for fewer work steps, saving valuable time.

Only few steps from sample to result

A woman in a white coat is performing a test on the Vivalytic Analyser in a laboratory. She is in the process of scanning the sample code. The picture contains a white box, in which you can read the text "1. Scan the sample code."
A woman in a white coat is standing in front of a Vivalytic Analyser and is scanning a cartridge. The picture contains a white box, in which you can read the text "2. Scan the cartridge code."
A hand in a hygienic glove that is placing sample material from a pipette into a Vivalytic cartridge. A Vivalytic Analyser is on the table next to the cartridge. The picture contains a white box, in which you can read the text "3. Fill in the sample and close the cartridge cover."
A cartridge is being inserted into a Vivalytic Analyser. There is a white box, in which you can read the text "4. Insert the cartridge – the test will start automatically."
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What exactly happens in the Vivalytic Analyser?

The Vivalytic Analyser automates complex, molecular diagnostic processes that previously had to be carried out manually. This promotes high safety and quick availability of the test results.

1. Step 2. Step 3. Step 4. Step 5. Step
1. Step
Preparing the sample
2. Step
Cell lysis
3. Step
Extraction of the nucleic acid
4. Step
DNA amplification
5. Step
Bio-analytical detection
1. Step
Preparing the sample
2. Step
Cell lysis
3. Step
Extraction of the nucleic acid
4. Step
DNA amplification
5. Step
Bio-analytical detection
1. Step
Samples are processed reliably.
2. Step
The external membrane of the cells is broken down through ultrasound.
3. Step
The nucleic acid (DNA/RNA) is purified for the PCR amplification.
4. Step
Specific DNA sequences are multiplied using PCR.
5. Step
The amplified DNA is identified by detecting a fluorescence or chemiluminescence signal.

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