Vivalytic PCR rapid test for the detection of Bordetella infection.

Comprehensive test results with the Vivalytic Bordetella test*

Bordetella pertussis is a gram-negative bacterium that causes an acute respiratory infection called pertussis or whooping cough. Bordetella holmesii, Bordetella parapertussis, and Bordetella bronchiseptica less commonly cause a whooping cough-like illness with a milder process.

Whooping cough can cause severe symptoms in people of all ages, which can be life-threatening, especially in infants. (1) About 15-20% of hospitalized patients get pneumonia as a result and about 1% of patients under 6 months of age die from the disease. (2) It is estimated that about 3-35% of Bordetella infections are caused by B. parapertussis. (3),(4)

Transmission of Bordetella infection is aerogenic via droplet infection. (5) A definitive diagnosis cannot be made purely on the basis of clinical symptoms, so laboratory diagnostics are crucial for making the diagnosis. Various methods are available for this, such as real-time PCR, culture and serology.

Real-time PCR enables rapid and targeted detection up to 4 weeks after the onset of symptoms. In addition, real-time PCR can be used to differentiate the human pathogenic Bordetella species. With the Vivalytic Bordetella test*, precise test results are available quickly and in laboratory quality.

Pathogens detectable with Vivalytic Bordetella

B. pertussis
B. parapertussis
B.holmesii

Vivalytic Bordetella– Fast laboratory testing for outbreak containment

Only a few steps from sample to result
No further laboratory equipment needed
Reduced risk of infection for the user

(1) World Health Organization 2011. pertussis. http://www.who.int/immunization/topics/pertussis/en/index.html. Abgerufen am 21.05.2013.

(2) https://www.impfen-info.de/impfempfehlungen/fuer-kinder-0-12-jahre/keuchhusten-pertussis/, abgerufen am 15.06.2023

(3) Linneman CC und Perry EB. Bordetella parapertussis. Recent experience and a review of the literature. Am J Dis Child. 1977, 131 (5): 560-563.

(4) Mertsola, J. Mixed outbreak of Bordetella pertussis and Bordetella parapertussis infection in Finland. Eur J Clin Microbiol. 1985, 4(2): 123-128.

(5) Robert Koch Institute 2013. pertussis (whooping cough). https://www.rki.de/DE/Content/Infekt/EpidBull/Merkblaetter/Ratgeber_Pertussis.html.

*Currently under development. Available as Research Use Only (RUO). Not for use in diagnostic procedures.

The advantages at a glance

Vivalytic stands for high efficiency and safety with minimum effort. The unique Vivalytic platform provides ideal assistance for everyday work in clinics, practices, and laboratories.

Comprehensive results

The Vivalytic Bordetella test utilises a two target approach to detect different pathogens.

High usability

The minimalistic design, easy handling and comprehensive depiction of the results ensure a high level of usability.

Easy handling

Like all Vivalytic tests, the Vivalytic Bordetella test is fully automated. This allows for fewer work steps, saving valuable time.

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Only few steps from sample to result

A woman in a white coat is performing a test on the Vivalytic Analyser in a laboratory. She is in the process of scanning the sample code. The picture contains a white box, in which you can read the text "1. Scan the sample code."

A woman in a white coat is standing in front of a Vivalytic Analyser and is scanning a cartridge. The picture contains a white box, in which you can read the text "2. Scan the cartridge code."

A hand in a hygienic glove that is placing sample material from a pipette into a Vivalytic cartridge. A Vivalytic Analyser is on the table next to the cartridge. The picture contains a white box, in which you can read the text "3. Fill in the sample and close the cartridge cover."

A cartridge is being inserted into a Vivalytic Analyser. There is a white box, in which you can read the text "4. Insert the cartridge – the test will start automatically."

What exactly happens in the Vivalytic Analyser?

The Vivalytic Analyser automates complex, molecular diagnostic processes that previously had to be carried out manually. This promotes high safety and quick availability of the test results.

1. Step	2. Step	3. Step	4. Step	5. Step
1. Step Preparing the sample	2. Step Cell lysis	3. Step Extraction of the nucleic acid	4. Step DNA amplification	5. Step Bio-analytical detection
1. Step	2. Step	3. Step	4. Step	5. Step
1. Step Samples are processed reliably.	2. Step The external membrane of the cells is broken down through ultrasound.	3. Step The nucleic acid (DNA/RNA) is purified for the PCR amplification.	4. Step Specific DNA sequences are multiplied using PCR.	5. Step The amplified DNA is identified by detecting a fluorescence or chemiluminescence signal.

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You can conveniently carry out updates remotely via the digital platform for Vivalytic products. This means that you will always have the latest tests available.

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